"Nobel Prize in Medicine" John Eccles Signed Album Page COA

Description: Up for auction the "Nobel Prize in Medicine" John Eccles Hand Signed Album Page. This item is certified authentic by Todd Mueller Autographs and comes with their Certificate of Authenticity. ES-4882E Sir John Carew Eccles AC FRS FRACP FRSNZ FAA (27 January 1903 – 2 May 1997) was an Australian neurophysiologist and philosopher who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize with Andrew Huxley and Alan Lloyd Hodgkin. Eccles was born in Melbourne, Australia. He grew up there with his two sisters and his parents: William and Mary Carew Eccles (both teachers, who home schooled him until he was 12). He initially attended Warrnambool High School (now Warrnambool College) (where a science wing is named in his honour), then completed his final year of schooling at Melbourne High School. Aged 17, he was awarded a senior scholarship to study medicine at the University of Melbourne. As a medical undergraduate, he was never able to find a satisfactory explanation for the interaction of mind and body; he started to think about becoming a neuroscientist. He graduated (with first class honours) in 1925, and was awarded a Rhodes Scholarship to study under Charles Scott Sherrington at Magdalen College, Oxford University, where he received his Doctor of Philosophy in 1929. In 1937 Eccles returned to Australia, where he worked on military research during World War II. During this time Eccles was the director of Kanematsu Institute at Sydney Medical School, he and Bernard Katz gave research lectures at the University of Sydney, strongly influencing its intellectual environment. After the war, he became a professor at the University of Otago in New Zealand. From 1952 to 1962 he worked as a professor at the John Curtin School of Medical Research (JCSMR) of the Australian National University. The Eccles Institute of Neuroscience is headquartered in a new wing of the JCSMR building, constructed with the assistance of a $63M grant from the Commonwealth Government and completed in March 2012. In the early 1950s, Eccles and his colleagues performed the research that would lead to his receiving the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch reflex as a model, which is easily studied because it consists of only two neurons: a sensory neuron (the muscle spindle fibre) and the motor neuron. The sensory neuron synapses onto the motor neuron in the spinal cord. When a current is passed into the sensory neuron in the quadriceps, the motor neuron innervating the quadriceps produced a small excitatory postsynaptic potential (EPSP). When a similar current is passed through the hamstring, the opposing muscle to the quadriceps, an inhibitory postsynaptic potential (IPSP) is produced in the quadriceps motor neuron. Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron can cause the motor neuron to fire, thus contracting the quadriceps. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing. Apart from these seminal experiments, Eccles was key to a number of important developments in neuroscience. Until around 1949, Eccles believed that synaptic transmission was primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led him and others to perform some of the experiments which proved chemical synaptic transmission. Bernard Katz and Eccles worked together on some of the experiments which elucidated the role of acetylcholine as a neurotransmitter in the brain.

Price: 149.99 USD

Location: Fort Lauderdale, Florida

End Time: 2025-02-11T13:24:08.000Z

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